IMC Version 9.5.0 Release Notes

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Category: IMC Release News

Also available:

The latest IMC Version 9.5.0 installer for Windows has been released.

The latest IMC Version 9.5.0 installer for macOS has been released.

• macOS 13 (Ventura), 14 (Sonoma), 15 (Sequoia), 26 (Tahoe), 27 (Golden Gate; if you use an LDK license, you may need to install Rosetta 2. See details here)
• Windows 11

New Features, Feature Changes/Improvements, Bug Fixes

Feature Migration

• Prokaryotic gene prediction (by MetaGeneAnnotator) has been migrated from processing on a remote Linux server (Annotation Server) to processing on the local PC (GENOME_ANALYSIS > ORF Finder). The remote Linux server is no longer required; it now runs directly on your local PC.
• Eukaryotic gene prediction (by AUGUSTUS) has been migrated from processing on a remote Linux server (Annotation Server) to processing on the local PC (GENOME_ANALYSIS > ORF Finder; IMC Premium OMICS Edition only). AUGUSTUS must be installed in advance to use this feature. See installation instructions here

Bug Fixes

• Fixed a bug where, with an Activation (SoftKey) license, IMC always launched as GE regardless of the edition (GE/PE).

Last Updated: 17 October 2026

Hits: 2827

IMC Version 9.4.0 Release Notes

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Category: IMC Release News

Also available:

The latest IMC Version 9.4.0 installer for Windows has been released.

The latest IMC Version 9.4.0 installer for macOS has been released.

• macOS 13 (Ventura), 14 (Sonoma), 15 (Sequoia), 26 (Tahoe), 27 (Golden Gate; if you use an LDK license, you may need to install Rosetta 2. See details here)
• Windows 11

New Features, Feature Changes/Improvements, Bug Fixes

New Features

• Added support for importing GeneMark.hmm prediction results (amino acid FASTA).

Feature Changes/Improvements

• Removed the Send to PlasmidMap button from the Fragment Table.

Bug Fixes

• Fixed a bug that prevented LDK license recognition on macOS 26 Tahoe.
• Fixed a bug where the scrollbar did not reach the end in PlasmidMap.
• Fixed a bug in the initial display of the Product Filter in Multi Fragment Assembly.
• Corrected inaccurate descriptions of Assembly methods.

Last Updated: 13 October 2026

Hits: 3390

Important Note When Upgrading to macOS 27 (Golden Gate)

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Category: Special Notices

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After upgrading to macOS 27, your LDK dongle (HardKey license) may not be recognized, and IMC may fall back to a software key license instead. This happens because Rosetta 2 - the compatibility layer that runs Intel-built software on Apple Silicon - is not installed by default on macOS 27.

If your dongle is not recognized, install Rosetta 2 as follows:

1. Open the Terminal app
2. Run the following command:
   softwareupdate --install-rosetta --agree-to-license
3. Restart IMC

Last Updated: 12 October 2026

Hits: 3072

IMC Version 9.3.0 Release Notes

Details

Category: IMC Release News

Also available:

The latest IMC Version 9.3.0 installer for Windows has been released.

The latest IMC Version 9.3.0 installer for macOS has been released.

• macOS 13 (Ventura), 14 (Sonoma), 15 (Sequoia), 26 (Tahoe, SoftKey License Only)
• Windows 11

New Features, Feature Changes/Improvements, Bug Fixes

New Features

• Cloning Workbench (beta)
• Integrated (Multiple) Ligation (beta)
• Ligation Simulation (beta)
• Graphical Tools for Ligation (beta)
• New Plasmid Map (beta)
• Fragment Assembly Primer Design (beta)
  • Golden Gate Assembly, etc.
• Construct Canvas (beta)
• DNA Fragment Assembly Workbench
  • See details here
• Added FBA and FVA to the Metabolic Pathway feature (beta)
• FBA/FVA results can now be shown as a series graph overlay on the Metabolic Pathway Canvas (beta)
• Added a sample Genome Scale Model install option
  • If you do not need the Genome Scale Model, please delete the model file.

Feature Changes/Improvements

• Significantly reduced IMC startup time
• You can now choose to show or hide each button individually, and change its display order within its group.
  • See details here
• Slightly adjusted the layout of the Cloning Workbench.
• Added the New Plasmid Map feature.
• Improved the Primer Design feature for Fragment Assembly.

Bug Fixes

• Fixed an issue where the state transitions of the Tool buttons on the Top, Bottom, Left, and Right of the Main Window were incorrect.
• Fixed several minor bugs in IMC.

Last Updated: 03 October 2026

Hits: 4304